IFNA5

Across TCGA patient cohorts, IFNA5 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFNA5-associated genes across cancer lineages are FoxM1, GSK-3_pS9, and GSK-3a-b_pS21_S9. Each is linked with IFNA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFNA5-to-partner and partner-to-IFNA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by IFNA5-low versus IFNA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFNA5→partner) and Y-score (partner→IFNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.299	+2.817	.035	.036	3	1
UCEC	GSK-3_pS9 →	-0.805	-3.169	<.001	.019	3	1
UCEC	GSK-3a-b_pS21_S9 →	-0.715	-2.990	.002	.036	3	1
UCEC	P-Cadherin →	+0.169	+3.009	.032	.019	3	1
UCEC	PCNA →	+0.342	+3.169	.003	.019	3	1
UCEC	ARID1A →	+0.228	+3.177	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FoxM1 by IFNA5 expression — UCEC

Explore this box plot interactively →