IFITM3P5

Across TCGA pan-cancer cohorts, IFITM3P5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IFITM3P5 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher IFITM3P5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFITM3P5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

LGG, KIRC, and UVM are the cancer types where IFITM3P5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.669	0.803	<.001	37	view →
KIRC	OS	Quartile	All	0.729	0.853	<.001	31	view →
UVM	OS	Quartile	III,IV	0.249	0.730	.019	18	view →
LUAD	DFS	Median	III,IV	0.676	0.347	.005	18	view →
STAD	DFS	Median	III,IV	0.486	0.714	.011	18	view →
ACC	DFS	Tertile	IV	0.065	0.373	.035	15	view →
KICH	DFS	Quartile	III,IV	0.285	0.887	.011	14	view →
SKCM	OS	Tertile	III,IV	0.629	0.176	<.001	13	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	13	view →
PRAD	DFS	Median	All	0.690	0.864	.013	12	view →
BLCA	OS	Quartile	IV	0.414	0.144	.003	11	view →
PCPG	OS	Median	All	1.000	0.731	.018	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IFITM3P5–LGG (DFS)

Open the LGG breakdown →