IFITM3

Across TCGA patient cohorts, IFITM3 protein abundance is significantly associated with the RNA expression of many other genes, with 14,691 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IFITM3-associated genes across cancer lineages are IFITM1, COL1A2, and P2RY6. Each is linked with IFITM3 in more than 5 cancer types. Because this analysis shows association rather than direction, both IFITM3-to-partner and partner-to-IFITM3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IFITM3 versus IFITM1 in GBM, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFITM3→partner) and Y-score (partner→IFITM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IFITM1 →	+1.200	+0.468	<.001	<.001	3	6
GBM	COL1A2 →	+1.447	+0.502	<.001	<.001	3	5
LUAD	P2RY6 →	+0.937	+0.234	<.001	.005	3	5
OV	IFITM2 →	+0.860	+0.510	.001	.001	3	5
GBM	BST2 →	+1.041	+0.585	<.001	<.001	3	5
LSCC	TRIM22 →	+1.078	+0.507	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,691 associations by consensus.

IFITM3 vs IFITM1 — GBM

Explore this scatter interactively →