IFITM3

Across TCGA cell cohorts, IFITM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,959 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFITM3-associated GO terms across cancer lineages are Negative regulation of viral process, Negative regulation of viral genome replication, and Defense response to virus. Each is linked with IFITM3 in more than 17 cancer types. Because this analysis shows association rather than direction, both IFITM3-to-partner and partner-to-IFITM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of viral process grouped by IFITM3-low versus IFITM3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFITM3→partner) and Y-score (partner→IFITM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of viral process →	+0.198	+2.274	<.001	<.001	3	18
KIDNEY	Negative regulation of viral genome replication →	+0.240	+2.368	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Defense response to virus →	+0.105	+4.927	<.001	<.001	3	17
SOFT_TISSUE	Host-mediated suppression of symbiont invasion →	+0.204	+2.355	<.001	<.001	3	17
KIDNEY	Response to interferon-alpha →	+0.178	+2.365	<.001	<.001	3	16
KIDNEY	Regulation of viral life cycle →	+0.128	+1.805	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,959 associations by consensus.

Negative regulation of viral process by IFITM3 expression — KIDNEY

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