IFIT5

Across TCGA pan-cancer cohorts, IFIT5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IFIT5 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IFIT5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFIT5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where IFIT5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.885	1.000	.017	48	view →
PDAC	OS	Quartile	II,III,IV	0.423	0.746	.009	10	view →
CCRCC	OS	Tertile	II,III,IV	0.896	0.277	.035	7	view →
LUAD	DFS	Tertile	III,IV	0.732	1.000	.038	6	view →
UCEC	DFS	Tertile	II,III,IV	0.727	1.000	.032	6	view →
LSCC	DFS	Quartile	All	1.000	0.416	.026	5	view →
HNSC	OS	Median	III,IV	1.000	0.484	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IFIT5–COAD (DFS)

Open the COAD breakdown →