IFIT5

Across TCGA patient cohorts, IFIT5 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFIT5-associated genes across cancer lineages are eIF4G, FoxM1, and Gab2. Each is linked with IFIT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFIT5-to-partner and partner-to-IFIT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by IFIT5-low versus IFIT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT5→partner) and Y-score (partner→IFIT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.377	+3.169	.009	.019	3	1
UCEC	FoxM1 →	+0.274	+2.584	.023	.011	2	2
UCEC	Gab2 →	+0.362	+2.584	.029	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.209	-3.321	.007	.010	3	1
UCEC	Ku80 →	+0.218	+2.598	.047	.006	3	1
UCEC	MEK1 →	+0.379	+2.584	.026	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4G by IFIT5 expression — UCEC

Explore this box plot interactively →