IFIT5

Across TCGA cell cohorts, IFIT5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,682 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFIT5-associated GO terms across cancer lineages are Negative regulation of viral process, Negative regulation of viral genome replication, and Defense response to virus. Each is linked with IFIT5 in more than 15 cancer types. Because this analysis shows association rather than direction, both IFIT5-to-partner and partner-to-IFIT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of viral process grouped by IFIT5-low versus IFIT5-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT5→partner) and Y-score (partner→IFIT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of viral process →	+0.178	+1.285	.006	.003	3	16
BREAST	Negative regulation of viral genome replication →	+0.200	+1.176	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Defense response to virus →	+0.088	+1.562	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Response to interferon-alpha →	+0.132	+0.868	<.001	<.001	3	14
OESOPHAGUS	Antiviral innate immune response →	+0.091	+1.195	<.001	.001	3	14
BLOOD_Lymphoma	Regulation of viral process →	+0.098	+1.530	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,682 associations by consensus.

Negative regulation of viral process by IFIT5 expression — KIDNEY

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