IFIT2

Across TCGA cell cohorts, IFIT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,546 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFIT2-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Negative regulation of viral genome replication, and Defense response to virus. Each is linked with IFIT2 in more than 17 cancer types. Because this analysis shows association rather than direction, both IFIT2-to-partner and partner-to-IFIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by IFIT2-low versus IFIT2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT2→partner) and Y-score (partner→IFIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.084	+2.400	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.205	+2.195	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Defense response to virus →	+0.088	+2.334	<.001	<.001	3	17
KIDNEY	Antiviral innate immune response →	+0.091	+1.611	<.001	<.001	3	17
KIDNEY	Negative regulation of viral process →	+0.174	+2.328	.005	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of viral process →	+0.116	+1.801	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,546 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by IFIT2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →