IFIT2

Across TCGA cell cohorts, IFIT2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFIT2-associated genes across cancer lineages are GAPDHS, OR12D2, and LRRC53. Each is linked with IFIT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFIT2-to-partner and partner-to-IFIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDHS grouped by IFIT2-low versus IFIT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT2→partner) and Y-score (partner→IFIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GAPDHS →	+0.046	+3.555	.007	.003	3	1
LARGE_INTESTINE	OR12D2 →	+0.042	+2.882	.003	.005	3	1
BLOOD_Leukemia	LRRC53 →	+0.019	+5.201	<.001	.006	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.029	+5.539	<.001	.003	3	1
LARGE_INTESTINE	CHRM5 →	+0.094	+3.459	.002	.003	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GAPDHS by IFIT2 expression — LARGE_INTESTINE

Explore this box plot interactively →