Across TCGA patient cohorts, IFIT1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFIT1-associated genes across cancer lineages are GSK-3_pS9, INPP4B, and Ku80. Each is linked with IFIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFIT1-to-partner and partner-to-IFIT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIT1→partner) and Y-score (partner→IFIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.453	-2.999	.010	.035	3	1
UCEC	INPP4B →	-0.282	-3.169	.046	.018	3	1
UCEC	Ku80 →	+0.215	+2.128	.037	.010	3	1
UCEC	MEK1 →	+0.443	+3.459	.005	.005	3	1
UCEC	Notch1 →	+0.229	+2.807	<.001	.003	3	1
UCEC	PCNA →	+0.312	+2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

IFIT1 survival (RNA) · tumor vs normal (RNA) · all IFIT1 data types