IFIH1

Across TCGA patient cohorts, IFIH1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFIH1-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and Caspase-7-cleavedD198. Each is linked with IFIH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IFIH1-to-partner and partner-to-IFIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by IFIH1-low versus IFIH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIH1→partner) and Y-score (partner→IFIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.164	-2.459	.015	.019	3	3
UCEC	Notch1 →	+0.178	+3.183	.001	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.573	+2.341	.016	.019	3	3
UCEC	eEF2 →	+0.359	+1.906	.012	.016	3	2
SKCM	EGFR_pY1173 →	+0.082	+1.597	.027	.040	3	2
UCEC	INPP4B →	-0.283	-1.874	.029	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

JNK_pT183_Y185 by IFIH1 expression — UCEC

Explore this box plot interactively →