IFIH1

Across TCGA cell cohorts, IFIH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,716 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IFIH1-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Antiviral innate immune response, and Innate immune response-activating signaling pathway. Each is linked with IFIH1 in more than 18 cancer types. Because this analysis shows association rather than direction, both IFIH1-to-partner and partner-to-IFIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by IFIH1-low versus IFIH1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIH1→partner) and Y-score (partner→IFIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Cytoplasmic pattern recognition receptor signaling pathway →	+0.084	+1.849	<.001	<.001	3	19
KIDNEY	Antiviral innate immune response →	+0.118	+2.070	.001	.001	3	17
OESOPHAGUS	Innate immune response-activating signaling pathway →	+0.088	+2.512	<.001	<.001	3	17
OESOPHAGUS	Positive regulation of interferon-beta production →	+0.114	+2.021	.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.217	+1.720	<.001	<.001	3	17
KIDNEY	Defense response to virus →	+0.105	+2.080	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,716 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by IFIH1 expression — CNS

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