IFIH1

Across TCGA cell cohorts, IFIH1 mutation is significantly associated with the RNA expression of many other genes, with 678 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFIH1-associated genes across cancer lineages are DNASE2B, NEIL2, and MMP26. Each is linked with IFIH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFIH1-to-partner and partner-to-IFIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNASE2B grouped by IFIH1-low versus IFIH1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFIH1→partner) and Y-score (partner→IFIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DNASE2B →	+0.058	+3.825	<.001	.001	3	2
LARGE_INTESTINE	NEIL2 →	+0.607	+2.584	.008	.002	3	2
LARGE_INTESTINE	MMP26 →	+0.023	+2.172	<.001	.007	3	2
LARGE_INTESTINE	TMEM220 →	+0.814	+3.619	<.001	<.001	3	2
LARGE_INTESTINE	MAML3 →	+0.826	+2.043	<.001	.008	3	2
LARGE_INTESTINE	TEX46 →	+0.170	+4.234	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 678 associations by consensus.

DNASE2B by IFIH1 expression — STOMACH

Explore this box plot interactively →