IFI6

Across TCGA patient cohorts, IFI6 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,260 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IFI6-associated proteins across cancer lineages are IRF9, ISG15, and MX2. Each is linked with IFI6 in more than 9 cancer types. Because this analysis shows association rather than direction, both IFI6-to-partner and partner-to-IFI6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IFI6 versus IRF9 in LSCC, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI6→partner) and Y-score (partner→IFI6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRF9 →	+0.514	+1.526	<.001	<.001	3	10
HNSC	ISG15 →	+1.265	+1.933	<.001	<.001	3	10
HNSC	MX2 →	+1.111	+2.116	<.001	<.001	3	10
LSCC	OAS2 →	+1.115	+1.845	<.001	<.001	3	10
HNSC	CMPK2 →	+0.857	+1.892	<.001	<.001	3	10
HNSC	IFIT1 →	+1.269	+2.030	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,260 associations by consensus.

IFI6 vs IRF9 — LSCC

Explore this scatter interactively →