IFI6

Across TCGA patient cohorts, IFI6 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI6-associated genes across cancer lineages are MIR8062, MIR379, and USP9YP36. Each is linked with IFI6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI6-to-partner and partner-to-IFI6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8062 grouped by IFI6-low versus IFI6-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI6→partner) and Y-score (partner→IFI6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR8062 →	+0.592	+8.471	<.001	.005	3	1
SKCM	MIR379 →	+0.378	+7.816	<.001	.008	3	1
SKCM	USP9YP36 →	+0.049	+7.816	<.001	.008	3	1
UCEC	MIR7976 →	+0.844	+4.038	<.001	.004	3	1
BRCA	RNA5SP346 →	+0.267	+7.731	<.001	.009	3	1
BRCA	TSPY18P →	+0.144	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MIR8062 by IFI6 expression — BRCA

Explore this box plot interactively →