IFI6

Across TCGA cell cohorts, IFI6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,759 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IFI6-associated GO terms across cancer lineages are Negative regulation of viral genome replication, Regulation of viral process, and Defense response to virus. Each is linked with IFI6 in more than 18 cancer types. Because this analysis shows association rather than direction, both IFI6-to-partner and partner-to-IFI6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of viral genome replication grouped by IFI6-low versus IFI6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI6→partner) and Y-score (partner→IFI6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of viral genome replication →	+0.242	+3.436	<.001	<.001	3	19
KIDNEY	Regulation of viral process →	+0.141	+4.072	<.001	<.001	3	19
KIDNEY	Defense response to virus →	+0.114	+4.668	<.001	<.001	3	18
KIDNEY	Regulation of viral life cycle →	+0.144	+4.534	<.001	<.001	3	17
OESOPHAGUS	Positive regulation of interferon-beta production →	+0.106	+2.918	.002	.002	3	17
KIDNEY	Positive regulation of canonical NF-kappaB signal transduction →	+0.081	+4.372	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,759 associations by consensus.

Negative regulation of viral genome replication by IFI6 expression — BREAST

Explore this box plot interactively →