IFI35

Across TCGA patient cohorts, IFI35 mutation is significantly associated with the RNA expression of many other genes, with 210 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI35-associated genes across cancer lineages are RNU6-990P, RNA5SP113, and GPATCH11. Each is linked with IFI35 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI35-to-partner and partner-to-IFI35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-990P grouped by IFI35-low versus IFI35-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI35→partner) and Y-score (partner→IFI35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-990P →	+2.027	+6.234	<.001	<.001	3	2
UCEC	RNA5SP113 →	+0.755	+3.641	<.001	.002	3	2
UCEC	GPATCH11 →	+0.610	+3.365	.001	.004	3	1
UCEC	EOMES →	+0.664	+3.459	.001	.005	3	1
UCEC	RP9 →	+0.497	+3.394	.002	.004	3	1
UCEC	TRUB2 →	+0.511	+3.222	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 210 associations by consensus.

RNU6-990P by IFI35 expression — BRCA

Explore this box plot interactively →