IFI27L2

Across TCGA pan-cancer cohorts, IFI27L2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IFI27L2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IFI27L2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IFI27L2 is over-expressed in tumor.

HNSC, PDAC, and CCRCC are the cancer types where IFI27L2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IFI27L2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.380	<.001	8	view →
PDAC	All	All	+0.561	.001	5	view →
CCRCC	Male	All	+0.546	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IFI27L2–HNSC

Open the HNSC breakdown →