IFI27

Across TCGA patient cohorts, IFI27 mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI27-associated genes across cancer lineages are LINC02283, OR5D15P, and RN7SKP295. Each is linked with IFI27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI27-to-partner and partner-to-IFI27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02283 grouped by IFI27-low versus IFI27-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI27→partner) and Y-score (partner→IFI27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02283 →	+0.105	+5.469	.004	.002	3	2
UCEC	OR5D15P →	+0.051	+4.453	.007	.006	3	2
SKCM	RN7SKP295 →	+0.204	+4.680	.004	.007	3	2
SKCM	LINC02855 →	+0.132	+4.875	<.001	.002	3	2
SKCM	GTF2F2P2 →	+0.051	+4.970	<.001	.005	3	1
SKCM	NEURL1-AS1 →	+0.147	+4.867	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

LINC02283 by IFI27 expression — SKCM

Explore this box plot interactively →