IFI27

Across TCGA cell cohorts, IFI27 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,123 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IFI27-associated GO terms across cancer lineages are Regulation of viral life cycle, Defense response to virus, and Antiviral innate immune response. Each is linked with IFI27 in more than 17 cancer types. Because this analysis shows association rather than direction, both IFI27-to-partner and partner-to-IFI27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of viral life cycle grouped by IFI27-low versus IFI27-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI27→partner) and Y-score (partner→IFI27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of viral life cycle →	+0.124	+4.703	<.001	<.001	2	18
KIDNEY	Defense response to virus →	+0.105	+6.765	.002	<.001	3	17
KIDNEY	Antiviral innate immune response →	+0.107	+4.905	.003	.004	3	16
BREAST	Negative regulation of response to biotic stimulus →	+0.093	+3.751	<.001	<.001	3	16
KIDNEY	Host-mediated perturbation of viral genome replication →	+0.145	+5.105	<.001	<.001	3	16
KIDNEY	Negative regulation of viral genome replication →	+0.213	+6.157	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,123 associations by consensus.

Regulation of viral life cycle by IFI27 expression — KIDNEY

Explore this box plot interactively →