IFI27

Across TCGA cell cohorts, IFI27 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFI27-associated genes across cancer lineages are DTHD1, ZNRF4, and CST8. Each is linked with IFI27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI27-to-partner and partner-to-IFI27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DTHD1 grouped by IFI27-low versus IFI27-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI27→partner) and Y-score (partner→IFI27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DTHD1 →	+0.056	+5.087	<.001	.004	3	1
LARGE_INTESTINE	ZNRF4 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	C20orf173 →	+0.035	+4.684	<.001	.002	3	1
LARGE_INTESTINE	OR10C1 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	APOC4 →	+0.123	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

DTHD1 by IFI27 expression — URINARY_TRACT

Explore this box plot interactively →