IFI16

Across TCGA pan-cancer cohorts, IFI16 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated IFI16 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IFI16 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IFI16 expression acts as an unfavorable survival marker.

UCEC, GBM, and CCRCC are the cancer types where IFI16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.482	0.944	.004	24	view →
GBM	DFS	Median	All	0.660	0.837	.002	19	view →
CCRCC	OS	Quartile	All	0.685	0.938	.006	15	view →
HNSC	DFS	Tertile	All	0.722	0.885	.011	14	view →
COAD	DFS	Quartile	II,III,IV	0.857	1.000	.029	12	view →
PDAC	OS	Median	II,III,IV	0.698	0.943	.006	10	view →
LUAD	OS	Median	All	0.671	0.945	.013	7	view →
LSCC	DFS	Median	All	0.739	0.845	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IFI16–UCEC (DFS)

Open the UCEC breakdown →