IFI16

Across TCGA patient cohorts, IFI16 protein abundance is significantly associated with the RNA expression of many other genes, with 13,431 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IFI16-associated genes across cancer lineages are OAS2, IFIT3, and XAF1. Each is linked with IFI16 in more than 7 cancer types. Because this analysis shows association rather than direction, both IFI16-to-partner and partner-to-IFI16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IFI16 versus OAS2 in HNSC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI16→partner) and Y-score (partner→IFI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OAS2 →	+1.368	+0.268	<.001	<.001	3	8
LSCC	IFIT3 →	+1.481	+0.416	<.001	<.001	3	8
OV	XAF1 →	+1.047	+0.339	<.001	<.001	3	8
BRCA	IL15RA →	+0.887	+0.529	<.001	<.001	3	8
HNSC	SP110 →	+0.962	+0.194	<.001	.005	3	8
OV	IFI44L →	+1.418	+0.472	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,431 associations by consensus.

IFI16 vs OAS2 — HNSC

Explore this scatter interactively →