IFI16

Across TCGA patient cohorts, IFI16 mutation is significantly associated with the RNA expression of many other genes, with 3,974 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI16-associated genes across cancer lineages are ELAC2, GLOD4, and MPLKIP. Each is linked with IFI16 in more than 3 cancer types. Because this analysis shows association rather than direction, both IFI16-to-partner and partner-to-IFI16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELAC2 grouped by IFI16-low versus IFI16-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI16→partner) and Y-score (partner→IFI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ELAC2 →	+0.421	+3.217	.003	.009	3	3
UCEC	GLOD4 →	+0.462	+2.010	<.001	<.001	3	3
UCEC	MPLKIP →	+0.309	+1.797	.005	<.001	3	3
UCEC	TIMM22 →	+0.439	+2.053	<.001	<.001	3	3
UCEC	FAM136A →	+0.414	+2.387	<.001	<.001	3	3
UCEC	NECAP1 →	+0.404	+2.010	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,974 associations by consensus.

ELAC2 by IFI16 expression — LUAD

Explore this box plot interactively →