IFI16

Across TCGA patient cohorts, IFI16 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFI16-associated genes across cancer lineages are Smac, Rictor_pT1135, and Cyclin-B1. Each is linked with IFI16 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI16-to-partner and partner-to-IFI16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by IFI16-low versus IFI16-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI16→partner) and Y-score (partner→IFI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Smac →	+0.557	+3.000	<.001	.036	3	2
STAD	Rictor_pT1135 →	-0.188	-3.000	.018	.036	3	2
UCEC	Cyclin-B1 →	+0.544	+1.906	.003	.014	3	2
COAD	GAPDH →	+0.663	+2.815	.017	.036	3	2
COAD	Lck →	+0.844	+2.832	<.001	.035	3	2
COAD	PCNA →	+0.324	+2.820	.017	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Smac by IFI16 expression — LUAD

Explore this box plot interactively →