IFI16

Across TCGA cell cohorts, IFI16 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,606 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IFI16-associated GO terms across cancer lineages are Positive regulation of canonical NF-kappaB signal transduction, Innate immune response-activating signaling pathway, and Cellular response to environmental stimulus. Each is linked with IFI16 in more than 11 cancer types. Because this analysis shows association rather than direction, both IFI16-to-partner and partner-to-IFI16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of canonical NF-kappaB signal transduction grouped by IFI16-low versus IFI16-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI16→partner) and Y-score (partner→IFI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of canonical NF-kappaB signal transduction →	+0.061	+2.958	<.001	.001	3	12
BLOOD_Myeloma	Innate immune response-activating signaling pathway →	+0.059	+2.138	.003	<.001	3	12
LIVER	Cellular response to environmental stimulus →	+0.049	+4.697	.001	<.001	3	11
LIVER	Cellular response to abiotic stimulus →	+0.049	+4.697	.001	<.001	3	11
LUNG_NSCLC_LUSC	Negative regulation of viral process →	+0.189	+3.191	.002	.001	3	11
LUNG_NSCLC_LUSC	Defense response to virus →	+0.098	+3.068	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,606 associations by consensus.

Positive regulation of canonical NF-kappaB signal transduction by IFI16 expression — SOFT_TISSUE

Explore this box plot interactively →