IFI16

Across TCGA cell cohorts, IFI16 mutation is significantly associated with the RNA expression of many other genes, with 297 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFI16-associated genes across cancer lineages are KRTAP3-3, DYDC1, and GALP. Each is linked with IFI16 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFI16-to-partner and partner-to-IFI16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP3-3 grouped by IFI16-low versus IFI16-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFI16→partner) and Y-score (partner→IFI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP3-3 →	+0.045	+5.247	<.001	.001	3	2
URINARY_TRACT	DYDC1 →	+0.073	+5.087	<.001	.004	3	1
URINARY_TRACT	GALP →	+0.036	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	BOD1L2 →	+0.006	+4.734	<.001	.002	3	1
SKIN	TEX43 →	+0.094	+4.217	<.001	.001	3	1
BLOOD_Lymphoma	BMP15 →	+0.021	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

KRTAP3-3 by IFI16 expression — BLOOD_Lymphoma

Explore this box plot interactively →