IFFO2

Across TCGA cell cohorts, IFFO2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFFO2-associated genes across cancer lineages are MYF5, GABRG1, and OR1J2. Each is linked with IFFO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFFO2-to-partner and partner-to-IFFO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF5 grouped by IFFO2-low versus IFFO2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFFO2→partner) and Y-score (partner→IFFO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MYF5 →	+0.756	+5.321	<.001	.005	3	1
LARGE_INTESTINE	GABRG1 →	+0.012	+4.196	<.001	.002	3	1
LARGE_INTESTINE	OR1J2 →	+0.071	+3.684	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MYF5 by IFFO2 expression — CNS

Explore this box plot interactively →