IFFO1

Across TCGA patient cohorts, IFFO1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IFFO1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR, and eIF4E. Each is linked with IFFO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFFO1-to-partner and partner-to-IFFO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by IFFO1-low versus IFFO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFFO1→partner) and Y-score (partner→IFFO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.914	+3.807	<.001	<.001	3	2
UCEC	EGFR →	-0.203	-3.000	.004	.036	3	1
UCEC	eIF4E →	+0.215	+2.700	.023	.006	3	1
UCEC	ERK2 →	+0.199	+3.169	.022	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.236	-3.459	.001	.005	3	1
UCEC	Ku80 →	+0.283	+2.013	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by IFFO1 expression — UCEC

Explore this box plot interactively →