IFFO1

Across TCGA cell cohorts, IFFO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,826 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IFFO1-associated GO terms across cancer lineages are PML body organization, Actin filament depolymerization, and Protein depolymerization. Each is linked with IFFO1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IFFO1-to-partner and partner-to-IFFO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML body organization grouped by IFFO1-low versus IFFO1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IFFO1→partner) and Y-score (partner→IFFO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PML body organization →	+0.169	+0.830	.002	.007	3	10
CNS	Actin filament depolymerization →	+0.160	+1.169	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Protein depolymerization →	+0.104	+0.855	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Negative regulation of hydrogen peroxide metabolic process →	+0.228	+0.928	<.001	.002	3	9
SKIN	Negative regulation of calcium ion export across plasma membrane →	+0.063	+1.648	<.001	.002	3	9
BREAST	Positive regulation of cell-substrate junction organization →	+0.087	+0.666	.007	.009	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,826 associations by consensus.

PML body organization by IFFO1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →