IFFO1

Across TCGA cell cohorts, IFFO1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IFFO1-associated genes across cancer lineages are FAM9A, SMIM23, and TBC1D21. Each is linked with IFFO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IFFO1-to-partner and partner-to-IFFO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM9A grouped by IFFO1-low versus IFFO1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IFFO1→partner) and Y-score (partner→IFFO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM9A →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SMIM23 →	+0.022	+5.569	<.001	.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR10Q1 →	+0.125	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR52H1 →	+0.031	+4.347	<.001	.001	3	1
CNS	OR11H6 →	+0.032	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FAM9A by IFFO1 expression — BLOOD_Leukemia

Explore this box plot interactively →