Across TCGA cell cohorts, IER5L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,598 significant associations in total. CNS shows the largest number of these associations.

The most reproducible IER5L-associated GO terms across cancer lineages are Regulation of pattern recognition receptor signaling pathway, Negative regulation of NLRP3 inflammasome complex assembly, and Cerebral cortex radially oriented cell migration. Each is linked with IER5L in more than 11 cancer types. Because this analysis shows association rather than direction, both IER5L-to-partner and partner-to-IER5L results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IER5L→partner) and Y-score (partner→IER5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.063	+1.166	.006	.009	3	12
SOFT_TISSUE	Negative regulation of NLRP3 inflammasome complex assembly →	+0.109	+1.610	<.001	<.001	3	11
CNS	Cerebral cortex radially oriented cell migration →	+0.134	+1.813	<.001	<.001	3	11
CNS	Cerebral cortex radial glia-guided migration →	+0.143	+1.670	<.001	<.001	3	11
CNS	Telencephalon glial cell migration →	+0.143	+1.670	<.001	<.001	3	11
LUNG_SCLC	Regulation of miRNA transcription →	+0.081	+0.979	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,598 associations by consensus.

Exploration

IER5L survival (RNA) · tumor vs normal (RNA) · all IER5L data types