Across TCGA cell cohorts, IER5L mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IER5L-associated genes across cancer lineages are VWA3B, LUZP4, and IFNG. Each is linked with IER5L in more than 1 cancer types. Because this analysis shows association rather than direction, both IER5L-to-partner and partner-to-IER5L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IER5L→partner) and Y-score (partner→IER5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	VWA3B →	+0.020	+4.285	.007	.003	3	1
BLOOD_Leukemia	LUZP4 →	+0.485	+5.060	<.001	.001	3	1
BLOOD_Leukemia	IFNG →	+0.220	+4.152	<.001	.009	3	1
BLOOD_Leukemia	FATE1 →	+0.126	+4.551	<.001	.004	3	1
BLOOD_Leukemia	IFNA2 →	+0.519	+4.705	<.001	.003	3	1
BLOOD_Leukemia	KRTDAP →	+0.132	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

IER5L survival (RNA) · tumor vs normal (RNA) · all IER5L data types