IER3

Across TCGA patient cohorts, IER3 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,191 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IER3-associated proteins across cancer lineages are PIK3C2A_S259, RETN, and RPRD2_S928. Each is linked with IER3 in more than 5 cancer types. Because this analysis shows association rather than direction, both IER3-to-partner and partner-to-IER3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IER3 versus PIK3C2A_S259 in LSCC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IER3→partner) and Y-score (partner→IER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIK3C2A_S259 →	+0.617	+1.017	<.001	<.001	3	6
GBM	RETN →	+1.664	+1.238	<.001	<.001	3	5
OV	RPRD2_S928 →	-0.567	-1.027	.003	<.001	3	5
GBM	ITGAM →	+0.743	+1.365	<.001	<.001	3	5
GBM	JUNB →	+0.418	+1.164	<.001	<.001	3	5
GBM	MPO →	+1.515	+1.449	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,191 associations by consensus.

IER3 vs PIK3C2A_S259 — LSCC

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