IER3

Across TCGA patient cohorts, IER3 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IER3-associated genes across cancer lineages are MIR320C2, MIR921, and RN7SKP151. Each is linked with IER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IER3-to-partner and partner-to-IER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR320C2 grouped by IER3-low versus IER3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IER3→partner) and Y-score (partner→IER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR320C2 →	+1.005	+5.037	<.001	.009	3	1
SKCM	MIR921 →	+0.830	+5.159	<.001	.007	3	1
SKCM	RN7SKP151 →	+0.178	+5.159	<.001	.007	3	1
UCEC	IGKV2OR2-2 →	+0.159	+3.344	.005	.008	3	1
UCEC	MIR8067 →	+0.721	+3.463	<.001	.003	3	1
UCEC	PRAMEF13 →	+0.035	+4.132	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MIR320C2 by IER3 expression — SKCM

Explore this box plot interactively →