IER3

Across TCGA cell cohorts, IER3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,302 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IER3-associated GO terms across cancer lineages are Urokinase plasminogen activator signaling pathway, Regulation of protein processing, and Regulation of T-helper 17 type immune response. Each is linked with IER3 in more than 13 cancer types. Because this analysis shows association rather than direction, both IER3-to-partner and partner-to-IER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Urokinase plasminogen activator signaling pathway grouped by IER3-low versus IER3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IER3→partner) and Y-score (partner→IER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Urokinase plasminogen activator signaling pathway →	+1.251	+2.953	.008	.006	3	14
SOFT_TISSUE	Regulation of protein processing →	+0.140	+2.291	<.001	<.001	3	12
BLOOD_Lymphoma	Regulation of T-helper 17 type immune response →	+0.074	+1.993	<.001	<.001	3	12
SOFT_TISSUE	Regulation of hemostasis →	+0.164	+2.199	<.001	<.001	3	11
SOFT_TISSUE	Regulation of blood coagulation →	+0.162	+2.199	<.001	<.001	3	11
LIVER	Regulation of plasminogen activation →	+0.293	+2.835	.002	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,302 associations by consensus.

Urokinase plasminogen activator signaling pathway by IER3 expression — LIVER

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