IER3-AS1

Across TCGA pan-cancer cohorts, IER3-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IER3-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IER3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IER3-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

HNSC, KIRC, and LUAD are the cancer types where IER3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.548	0.697	<.001	124	view →
KIRC	OS	Tertile	II,III,IV	0.625	0.787	.002	100	view →
LUAD	DFS	Median	All	0.710	0.866	<.001	72	view →
KICH	DFS	Quartile	All	0.663	1.000	.004	71	view →
KIRP	OS	Median	II,III,IV	0.701	0.927	.003	54	view →
LIHC	DFS	Median	All	0.461	0.617	<.001	51	view →
UCS	OS	Median	IV	0.302	0.817	.002	36	view →
STAD	OS	Quartile	All	0.402	0.661	.008	33	view →
ESCA	OS	Quartile	III,IV	0.409	0.810	.003	29	view →
BRCA	OS	Tertile	III,IV	0.951	0.858	.006	27	view →
BLCA	DFS	Quartile	III,IV	0.433	0.198	.003	24	view →
UVM	OS	Tertile	All	0.463	0.791	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IER3-AS1–HNSC (DFS)

Open the HNSC breakdown →