IDUA

Across TCGA pan-cancer cohorts, IDUA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IDUA data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IDUA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IDUA expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where IDUA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	1.000	0.321	.001	16	view →
CCRCC	DFS	Tertile	III,IV	0.140	0.915	.017	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
HNSC	OS	Median	IV	0.634	0.856	.020	8	view →
LSCC	DFS	Tertile	II,III,IV	0.555	0.828	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IDUA–LUAD (OS)

Open the LUAD breakdown →