IDUA

Across TCGA pan-cancer cohorts, IDUA mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IDUA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IDUA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IDUA is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and HNSC are the cancer types where IDUA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IDUA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.271	<.001	9	view →
LSCC	All	III,IV	−0.553	<.001	8	view →
HNSC	All	II,III,IV	−0.224	.003	6	view →
PDAC	Female	III,IV	−0.720	.006	2	view →
LUAD	Female	All	+0.196	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IDUA–COAD

Open the COAD breakdown →