IDUA

Across TCGA patient cohorts, IDUA protein abundance is significantly associated with the RNA expression of many other genes, with 19,854 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IDUA-associated genes across cancer lineages are TXNDC15, CDCA2, and KLHDC1. Each is linked with IDUA in more than 7 cancer types. Because this analysis shows association rather than direction, both IDUA-to-partner and partner-to-IDUA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IDUA versus TXNDC15 in BRCA, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDUA→partner) and Y-score (partner→IDUA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TXNDC15 →	+0.519	+0.362	<.001	<.001	3	8
UCEC	CDCA2 →	-1.212	-0.483	<.001	<.001	3	7
BRCA	KLHDC1 →	+0.718	+0.470	<.001	<.001	3	7
OV	SSPN →	+0.915	+0.395	.003	.002	3	6
UCEC	LRRC4C →	+0.982	+0.465	.001	<.001	3	6
UCEC	PBK →	-1.248	-0.488	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,854 associations by consensus.

IDUA vs TXNDC15 — BRCA

Explore this scatter interactively →