IDUA

Across TCGA patient cohorts, IDUA mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDUA-associated genes across cancer lineages are aDC, Mesangial cells, and Basophils. Each is linked with IDUA in more than 1 cancer types. Because this analysis shows association rather than direction, both IDUA-to-partner and partner-to-IDUA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, aDC grouped by IDUA-low versus IDUA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDUA→partner) and Y-score (partner→IDUA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	aDC →	+0.075	+2.839	.028	.034	3	1
UCEC	Mesangial cells →	-0.056	-2.574	.001	.011	3	1
UCEC	Basophils →	+0.244	+2.584	.002	.011	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

aDC by IDUA expression — UCEC

Explore this box plot interactively →