IDUA

Across TCGA cell cohorts, IDUA mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IDUA-associated genes across cancer lineages are FAM71C, MROH9, and CHRNB3. Each is linked with IDUA in more than 1 cancer types. Because this analysis shows association rather than direction, both IDUA-to-partner and partner-to-IDUA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71C grouped by IDUA-low versus IDUA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDUA→partner) and Y-score (partner→IDUA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM71C →	+0.195	+3.475	<.001	.006	3	2
LUNG_NSCLC_LUAD	MROH9 →	+0.177	+3.201	<.001	.004	3	1
SKIN	CHRNB3 →	+0.009	+3.882	<.001	.001	3	1
SKIN	HPGDS →	+0.069	+3.823	<.001	.006	3	1
SKIN	KRTAP6-1 →	+0.050	+4.022	<.001	.006	3	1
SKIN	AKAIN1 →	+0.062	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM71C by IDUA expression — BLOOD_Leukemia

Explore this box plot interactively →