Across TCGA patient cohorts, IDO2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDO2-associated genes across cancer lineages are p38-MAPK, IRS1, and Caspase-8. Each is linked with IDO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IDO2-to-partner and partner-to-IDO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDO2→partner) and Y-score (partner→IDO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p38-MAPK →	-0.154	-3.312	.020	.010	3	2
UCEC	IRS1 →	+0.279	+3.169	.002	.019	3	2
UCEC	Caspase-8 →	-0.247	-2.558	.024	.010	3	2
SKCM	Bax →	-0.172	-2.584	.049	.001	3	2
LUSC	Mre11 →	-0.141	-2.972	.009	.035	3	1
LUSC	NF-kB-p65_pS536 →	+0.368	+2.179	.043	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

IDO2 survival (RNA) · tumor vs normal (RNA) · all IDO2 data types