Across TCGA cell cohorts, IDO2 mutation is significantly associated with the mutation status of many other genes, with 246 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IDO2-associated genes across cancer lineages are ZBTB10, RAD51AP2, and NF1. Each is linked with IDO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IDO2-to-partner and partner-to-IDO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDO2→partner) and Y-score (partner→IDO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZBTB10 →	+4.297	+4.857	.009	.009	1	2
BLOOD_Leukemia	RAD51AP2 →	+4.000	+5.050	.008	.008	1	2
SKIN	NF1 →	+2.509	+4.384	<.001	<.001	1	2
SKIN	PCDHA5 →	+3.094	+4.850	<.001	<.001	1	2
SKIN	ADAMTS17 →	+4.187	+4.532	<.001	<.001	1	2
SKIN	ZP1 →	+3.772	+3.772	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

Exploration

IDO2 survival (RNA) · tumor vs normal (RNA) · all IDO2 data types