IDO1

Across TCGA pan-cancer cohorts, IDO1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IDO1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IDO1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IDO1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where IDO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.772	0.943	.005	4	view →
PDAC	OS	Median	II,III,IV	0.556	0.227	.003	4	view →
LSCC	OS	Median	II,III,IV	0.637	0.881	.034	4	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	3	view →
GBM	OS	Tertile	All	0.767	0.891	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IDO1–UCEC (DFS)

Open the UCEC breakdown →