IDO1

Across TCGA patient cohorts, IDO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,463 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IDO1-associated proteins across cancer lineages are APOL3, GBP4, and PSME2. Each is linked with IDO1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IDO1-to-partner and partner-to-IDO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IDO1 versus APOL3 in HNSC, with a Pearson correlation of 0.63.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IDO1→partner) and Y-score (partner→IDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	APOL3 →	+0.779	+1.935	<.001	<.001	3	10
HNSC	GBP4 →	+0.948	+2.258	<.001	<.001	3	10
HNSC	PSME2 →	+0.470	+2.057	<.001	<.001	3	10
GBM	IFIH1_S301 →	+0.844	+0.984	<.001	.002	3	9
GBM	IFIT1 →	+0.884	+0.863	<.001	<.001	3	9
HNSC	IFIT3 →	+1.067	+1.595	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,463 associations by consensus.

IDO1 vs APOL3 — HNSC

Explore this scatter interactively →