IDO1

Across TCGA patient cohorts, IDO1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,099 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IDO1-associated genes across cancer lineages are IL15, IFIH1, and GBP1. Each is linked with IDO1 in more than 8 cancer types. Because this analysis shows association rather than direction, both IDO1-to-partner and partner-to-IDO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IDO1 versus IL15 in OV, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDO1→partner) and Y-score (partner→IDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IL15 →	+0.912	+1.185	<.001	<.001	3	9
BRCA	IFIH1 →	+0.996	+1.023	.001	<.001	3	8
COAD	GBP1 →	+1.588	+1.018	<.001	<.001	3	8
COAD	IFIT3 →	+1.641	+1.448	.001	<.001	3	8
HNSC	CD274 →	+1.510	+1.430	<.001	<.001	3	8
COAD	NMI →	+1.091	+1.484	.006	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,099 associations by consensus.

IDO1 vs IL15 — OV

Explore this scatter interactively →