IDO1

Across TCGA patient cohorts, IDO1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDO1-associated genes across cancer lineages are eEF2, eIF4E, and JNK_pT183_Y185. Each is linked with IDO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IDO1-to-partner and partner-to-IDO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by IDO1-low versus IDO1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDO1→partner) and Y-score (partner→IDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.298	+1.874	.018	.049	3	2
SKCM	eIF4E →	+0.170	+2.459	.011	.018	3	2
SKCM	JNK_pT183_Y185 →	-0.128	-3.807	.013	<.001	3	2
UCEC	MEK1 →	+0.440	+2.502	.002	.002	3	2
UCEC	Notch1 →	+0.175	+2.502	.001	.002	3	2
UCEC	STAT3_pY705 →	-0.488	-1.584	<.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eEF2 by IDO1 expression — SKCM

Explore this box plot interactively →