IDO1

Across TCGA cell cohorts, IDO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,232 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IDO1-associated GO terms across cancer lineages are Regulation of viral life cycle, Antigen processing and presentation of exogenous peptide antigen via MHC class Ib, and Positive regulation of canonical NF-kappaB signal transduction. Each is linked with IDO1 in more than 11 cancer types. Because this analysis shows association rather than direction, both IDO1-to-partner and partner-to-IDO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of viral life cycle grouped by IDO1-low versus IDO1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IDO1→partner) and Y-score (partner→IDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of viral life cycle →	+0.140	+0.629	.001	.003	3	12
SOFT_TISSUE	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.346	+1.355	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of canonical NF-kappaB signal transduction →	+0.069	+2.419	<.001	.002	3	11
KIDNEY	Defense response to virus →	+0.109	+0.603	<.001	.005	3	10
PANCREAS	Negative regulation of response to biotic stimulus →	+0.102	+1.941	<.001	<.001	3	10
PANCREAS	Antigen processing and presentation →	+0.105	+1.605	.004	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,232 associations by consensus.

Regulation of viral life cycle by IDO1 expression — KIDNEY

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