IDH3A

Across TCGA patient cohorts, IDH3A protein abundance is significantly associated with the RNA expression of many other genes, with 10,148 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IDH3A-associated genes across cancer lineages are SERPINH1, COX5A, and MRPL3. Each is linked with IDH3A in more than 4 cancer types. Because this analysis shows association rather than direction, both IDH3A-to-partner and partner-to-IDH3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IDH3A versus SERPINH1 in BRCA, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH3A→partner) and Y-score (partner→IDH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINH1 →	-0.837	-0.277	<.001	<.001	3	5
OV	COX5A →	+0.640	+0.390	<.001	<.001	3	4
BRCA	MRPL3 →	-0.453	-0.277	.001	.001	3	4
COAD	TNFAIP6 →	-1.197	-0.284	<.001	<.001	3	4
COAD	TREM1 →	-0.902	-0.238	<.001	<.001	3	4
LUAD	SUMO3 →	-0.463	-0.281	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,148 associations by consensus.

IDH3A vs SERPINH1 — BRCA

Explore this scatter interactively →